If ketamine therapy works for me, how soon after my first dose should I expect to feel better?

Some patients will begin to feel better within hours of the first infusion. Patients with thoughts of self-harm often notice those thoughts dissipating first. There can be a dramatic relief of dread and hopelessness. Other patients may not notice any mood improvement until the next day. Some patients will require a second (or even a third) infusion before feeling better.